Effect Of Pearl Millet (Pennisetum Glaucum) On Some Sex Hormones In Streptozocin Induced Rat Models Of Type-2 Diabetes Mellitus

Abstract

This study used 30 adult albino male Sprague-Dawley strain rats to determine the therapeutic effect of Pearl Millet on certain sex hormones in a type-2 diabetes mellitus male rat model. The rats were divided into five groups of six rats each.  The first, third, fourth, and fifth group rats were induced with steptozocin STZ (40 mg/kg, IP) and classed into control positive (+ve) group (fed on basal diet only), group treated with (30% pearl millet from b.w), and group treated with steptozocin STZ (40 mg/kg, IP) alone. , group treated with (60 %pearl millet from b.w) and group treated with (100 %pearl millet from b.w) .The outcomes showed that insulin glutathione reduced (GSH), catalase (CAT), and glutathione peroxidase (GPX) levels significantly decreased in the control (+ve) group. superoxide dismutase (SOD), High density lipoprotein (HDL), Dehydroepiandrosterone (DHEA), Estradiol, Progesterone, Testosterone, Prolactin (PRL), Despite a considerable rise in blood glucose, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) , Low density lipoprotein (LDL), triglyceride (TG), cholesterol (CH), and very Low density lipoprotein (VLDL) compare with control (- ve) group. While showed in (30, 60, 100% of pearl millet) significant decrease in blood glucose, LDL, TG, CH and VLDL but found significant increase in insulin GSH, CAT, GPX , SOD, HDL, DHEA, Estradiol, Progesterone, Testosterone, PRL, LH and FSH compared with control (+ ve).